Tricyclic antidepressants updated on 07-01-2025

Childhood asthma

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11248
R41381		 Liu, 2015 Asthma in the offspring during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes Monotherapy: TCA only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.28 [1.06;1.56] -/409   1,727/12,476 - 409
ref
Total 1 studies 1.28 [1.06;1.55] 0 409
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Liu, 2015Liu, 2015 1.28[1.06; 1.56]-4090%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.28[1.06; 1.55]-409 -NALiu, 2015 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.28[1.06; 1.55]-409 -NALiu, 2015 1 Tags Adjustment   - Yes  - Yes 1.28[1.06; 1.55]-409 -NALiu, 2015 1 Monotherapy   - TCA only  - TCA only 1.28[1.06; 1.55]-409 -NALiu, 2015 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.28[1.06; 1.55]-409 -NALiu, 2015 1 All studiesAll studies 1.28[1.06; 1.55]-409 -NALiu, 2015 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.28[1.06; 1.55]1,718409 -NALiu, 2015 10.510.01.0