| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| S18373 R77495 |
Heuvelman, 2023 | Attention deficit hyperactivity disorder -Medical codes or therapy records that indicated that the child had been prescribed ADHD medication - Mean age at end of follow-up 10.04 years, range 4–22 years | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) | 1.24 [0.83;1.85] | -/2,148 -/16,330 | - | 2,148 |
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| S18136 R76890 |
Hartwig, 2022 | Attention-deficit/hyperactivity disorder (ADHD) - Children receiving medication for ADHD before the age of 16 years - Follow up from at least 4 years old | during pregnancy (anytime or not specified) | case control | sibling | Adjustment: Yes Monotherapy: no or not specified | 1.43 [0.75;9.26] | -/- 0/- | - | - |
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| S18247 R76891 |
Suarez (Controls unexposed, discontinuers), 2022 | Attention Deficit Hyperactivity Disorder - ≥ 2 dates with ICD-9 Dx 314.xx or ≥ 2 dispensings or 1 diagnosis and 1 dispensing - At ≥ 2 years of age | 2nd and/or 3rd trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes Monotherapy: no or not specified Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) | 1.08 [0.83;1.41] | 172/4,307 180/5,710 | 352 | 4,307 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18248 R76892 |
Suarez (Controls unexposed, general pop), 2022 | Attention Deficit Hyperactivity Disorder - ≥ 2 dates with ICD-9 Dx 314.xx or ≥ 2 dispensings or 1 diagnosis and 1 dispensing - At ≥ 2 years of age | 2nd and/or 3rd trimester | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: Yes Monotherapy: no or not specified |
1.01 [0.86;1.18] excluded (control group) |
174/4,357 52,361/2,965,988 | 52,535 | 4,357 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S10946 R46862 |
Boukhris (Controls exposed to SSRIs), 2017 | Infants with attention deficit hyperactivity disorder (ADHD-ICD9: 314.0; 314.01; 314.9; ICD10:F90;F90.0;F90.1;F90.2; F90.8;F90.9 or ADHD medications) - Mean 6-7 years old (0-11 years) | 2nd and/or 3rd trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No Monotherapy: TCA only |
1.30 [0.75;2.26] C excluded (control group) |
16/227 86/1,561 | 102 | 227 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S10948 R46863 |
Boukhris (Controls unexposed, NOS), 2017 | Infants with attention deficit hyperactivity disorder (ADHD-ICD9: 314.0; 314.01; 314.9; ICD10:F90;F90.0;F90.1;F90.2; F90.8;F90.9 or ADHD medications) - Mean 6-7 years old (0-11 years) | 2nd and/or 3rd trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: TCA only | 1.80 [1.00;3.10] | 16/227 4,430/141,905 | 4,446 | 227 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11328 R46864 |
Laugesen, 2013 | Attention deficit hyperactivity disorder ADHD (diagnosis of ADHD or a redemption of a prescription for ADHD medication) - Median 8 years old (1-14 years) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: TCA only | 1.10 [0.60;2.00] | -/716 -/816,792 | - | 716 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 5 studies | 1.19 [0.98;1.45] | 4,798 | 7,398 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Controls unexposed, discontinuers; 2: Controls unexposed, NOS;
Asymetry test p-value = 0.3229 (by Egger's regression)
slope=-0.0171 (0.1815); intercept=0.9755 (0.8263); t=1.1806; p=0.3229
excluded 10946, 18248