Tricyclic antidepressants updated on 07-01-2025

Ear, face and neck anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10937
R40715		 Ban (Controls exposed to SSRIs), 2014 Ear, face, and neck malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: TCA only 3.16 [0.06;159.55] C
excluded (control group) 		0/2,428   0/7,683 0 2,428
ref
S10938
R40731		 Ban (Controls unexposed, disease free), 2014 Ear, face, and neck malformations 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No Monotherapy: TCA only 0.80 [0.05;12.94] C
excluded (control group) 		0/2,428   83/325,294 83 2,428
ref
S10939
R40753		 Ban (Controls unexposed, sick), 2014 Ear, face, and neck malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No Monotherapy: TCA only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.37 [0.02;6.46] C 0/2,428   7/13,432 7 2,428
ref
S10930
R40599		 Davis, 2007 Congenital anomalies of ear, face, and neck 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.70 [0.04;11.31] C 0/167   211/49,669 211 167
ref
Total 2 studies 0.51 [0.07;3.77] 218 2,595
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ban (Controls unexposed, sick), 2014Ban, 2014 1 0.37[0.02; 6.46]72,42849%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Davis, 2007Davis, 2007 0.70[0.04; 11.31]21116751%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.51[0.07; 3.77]2182,5950.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.51[0.07; 3.77]2182,5950%NABan (Controls unexposed, sick), 2014 Davis, 2007 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.70[0.04; 11.31]211167 -NADavis, 2007 1 unexposed, sickunexposed, sick 0.37[0.02; 6.46]72,428 -NABan (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 0.51[0.07; 3.77]2182,5950%NABan (Controls unexposed, sick), 2014 Davis, 2007 2 Monotherapy   - no or not specified  - no or not specified 0.70[0.04; 11.31]211167 -NADavis, 2007 1   - TCA only  - TCA only 0.37[0.02; 6.46]72,428 -NABan (Controls unexposed, sick), 2014 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.37[0.02; 6.46]72,428 -NABan (Controls unexposed, sick), 2014 1 All studiesAll studies 0.51[0.07; 3.77]2182,5950%NABan (Controls unexposed, sick), 2014 Davis, 2007 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10937, 10938

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.75[0.11; 5.36]2942,5950%NABan (Controls unexposed, disease free), 2014 Davis, 2007 2 unexposed, sick controlsunexposed, sick controls Out of scale0.37[0.02; 6.46]72,428 -NABan (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.16[0.06; 159.55]-2,428 -NABan (Controls exposed to SSRIs), 2014 10.510.01.0