| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S18445 R78339 |
Lee (Controls exposed to SSRI), 2025 | Small for gestational age (birth weight <2 standard deviations below the mean for gestational age) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No Monotherapy: TCA only |
1.20 [0.64;2.25] C excluded (control group) |
15/613 30/1,465 | 45 | 613 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18410 R77740 |
Lee (Controls unexposed, general pop), 2025 | Small for gestational age (birth weight <2 standard deviations below the mean for gestational age) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: TCA only | 1.07 [0.63;1.81] | 15/613 6,986/463,440 | 7,001 | 613 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18222 R76451 |
Martin - Amitriptyline, 2024 | Small for gestational age (SGA, defined as those with a birth weight in the lowest 10 percentiles for gestational age (<10th percentile) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) | 1.00 [0.90;1.11] | 433/3,859 229,066/2,408,707 | 229,499 | 3,859 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S10933 R41672 |
Reis (Controls exposed to SSRIs), 2010 | Small for gestational age (<2 S.D. from expected weight) | 2nd and/or 3rd trimester | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: No Monotherapy: TCA only |
0.70 [0.40;1.22] C excluded (control group) |
14/784 122/4,809 | 136 | 784 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S10934 R41665 |
Reis (Controls unexposed, NOS), 2010 | Small for gestational age (<2 S.D. from expected weight) | 2nd and/or 3rd trimester | population based cohort retrospective | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: TCA only | 0.77 [0.45;1.32] | 14/784 24,802/1,062,190 | 24,816 | 784 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 3 studies | 0.99 [0.90;1.10] | 261,316 | 5,256 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Controls unexposed, general pop; 2: Controls unexposed, NOS;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 10933, 18445