Caftor

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18836
R80245		 Chouchana (Controls unexposed, disease free), 2025 Hospitalization in neonatal unit (including intensive unit) at least 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 3.22 [1.96;5.27] C
excluded (control group) 		18/147   160,062/3,849,289 160,080 147
ref
S18835
R80229		 Chouchana (Controls unexposed, sick), 2025 Hospitalization in neonatal unit (including intensive unit) at least 1st trimester excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 0.98 [0.55;1.73] C
excluded (exposition period) 		18/147   55/441 73 147
ref
S18837
R80252		 Jain, 2025 Neonatal Intensive Care Unit stay during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 1.29 [0.68;2.43] C 25/75   31/111 56 75
ref
Total 1 studies 1.29 [0.68;2.43] 56 75
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Jain, 2025Jain, 2025 1.29[0.68; 2.43]56750%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: criticalROB mesure: moderateROB reporting: critical0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.29[0.68; 2.43]5675 -NAJain, 2025 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.29[0.68; 2.43]5675 -NAJain, 2025 1 Tags Adjustment   - No  - No 1.29[0.68; 2.43]5675 -NAJain, 2025 1 All studiesAll studies 1.29[0.68; 2.43]5675 -NAJain, 2025 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18836

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.29[0.68; 2.43]5675 -NAJain, 2025 10.510.01.0