Caftor

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18834
R80213		 Salvatore, 2026 Preterm births throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 1.01 [0.43;2.38] C 10/40   24/97 34 40
ref
S18836
R80237		 Chouchana (Controls unexposed, disease free), 2025 Preterm birth (< 37 weeks) at least 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 4.98 [3.35;7.40] C
excluded (control group) 		31/147   196,091/3,849,289 196,122 147
ref
S18835
R80221		 Chouchana (Controls unexposed, sick), 2025 Preterm birth (< 37 weeks) at least 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No 1.19 [0.75;1.89] C 31/147   81/441 112 147
ref
S18837
R80248		 Jain, 2025 Preterm birth (< 37 weeks’ gestation) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 0.82 [0.46;1.46] C 26/86   48/139 74 86
ref
Total 3 studies 1.03 [0.74;1.43] 220 273
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Salvatore, 2026Salvatore, 2026 1.01[0.43; 2.38]344015%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Chouchana (Controls unexposed, sick), 2025Chouchana, 2025 1 1.19[0.75; 1.89]11214752%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Jain, 2025Jain, 2025 0.82[0.46; 1.46]748633%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: criticalROB mesure: moderateROB reporting: critical Total (3 studies) I2 = 0% 1.03[0.74; 1.43]2202730.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.74; 1.43]2202730%NASalvatore, 2026 Chouchana (Controls unexposed, sick), 2025 Jain, 2025 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.03[0.74; 1.43]2202730%NASalvatore, 2026 Chouchana (Controls unexposed, sick), 2025 Jain, 2025 3 Tags Adjustment   - No  - No 1.03[0.74; 1.43]2202730%NASalvatore, 2026 Chouchana (Controls unexposed, sick), 2025 Jain, 2025 3 All studiesAll studies 1.03[0.74; 1.43]2202730%NASalvatore, 2026 Chouchana (Controls unexposed, sick), 2025 Jain, 2025 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18836

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.98[3.35; 7.40]196,122147 -NAChouchana (Controls unexposed, disease free), 2025 1 unexposed, sick controlsunexposed, sick controls 1.03[0.74; 1.43]2202730%NASalvatore, 2026 Chouchana (Controls unexposed, sick), 2025 Jain, 2025 30.510.01.0