Caftor

Extremely preterm (< 28 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18836
R80240		 Chouchana (Controls unexposed, disease free), 2025 Extreme preterm birth < 28 weeks at least 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.23 [0.08;19.77] C
excluded (control group) 		0/147   10,648/3,849,289 10,648 147
ref
S18835
R80224		 Chouchana (Controls unexposed, sick), 2025 Extreme preterm birth < 28 weeks at least 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No 0.33 [0.02;6.19] C 0/147   4/441 4 147
ref
Total 1 studies 0.33 [0.02;6.19] 4 147
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chouchana (Controls unexposed, sick), 2025Chouchana, 2025 1 0.33[0.02; 6.19]41470%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.33[0.02; 6.19]4147 -NAChouchana (Controls unexposed, sick), 2025 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.33[0.02; 6.19]4147 -NAChouchana (Controls unexposed, sick), 2025 1 Tags Adjustment   - No  - No 0.33[0.02; 6.19]4147 -NAChouchana (Controls unexposed, sick), 2025 1 All studiesAll studies 0.33[0.02; 6.19]4147 -NAChouchana (Controls unexposed, sick), 2025 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18836

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.23[0.08; 19.77]10,648147 -NAChouchana (Controls unexposed, disease free), 2025 1 unexposed, sick controlsunexposed, sick controls Out of scale0.33[0.02; 6.19]4147 -NAChouchana (Controls unexposed, sick), 2025 10.510.01.0