Mirtazapine updated on 07-01-2025

Jaundice / Icterus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12919
R49010		 Gungor (Controls exposed to SSRI), 2019 Neonatal bilirubinemia (transient-mild) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.26 [0.06;1.03] C
excluded (control group) 		3/16   19/40 22 16
ref
S12920
R49016		 Gungor (Controls unexposed, disease free), 2019 Neonatal bilirubinemia (transient-mild) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.10 [0.21;5.74] C
excluded (control group) 		3/16   4/23 7 16
ref
S12921
R49022		 Gungor (Controls unexposed, sick), 2019 Neonatal bilirubinemia (transient-mild) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: old history of illness/treatment (> 12 months before pregnancy) or not specified 0.25 [0.06;1.13] C 3/16   11/23 14 16
ref
Total 1 studies 0.25 [0.06;1.13] 14 16
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gungor (Controls unexposed, sick), 2019Gungor, 2019 1 0.25[0.06; 1.13]14160%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.25[0.06; 1.13]1416 -NAGungor (Controls unexposed, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.25[0.06; 1.13]1416 -NAGungor (Controls unexposed, sick), 2019 1 Tags Adjustment   - No  - No 0.25[0.06; 1.13]1416 -NAGungor (Controls unexposed, sick), 2019 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.25[0.06; 1.13]1416 -NAGungor (Controls unexposed, sick), 2019 1 Unexposed sick   - old history of illness/treatment (> ...  - old history of illness/treatment (> 12 months before pregnancy) or not specified 0.25[0.06; 1.13]1416 -NAGungor (Controls unexposed, sick), 2019 1 All studiesAll studies 0.25[0.06; 1.13]1416 -NAGungor (Controls unexposed, sick), 2019 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12919, 12920

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.10[0.21; 5.74]716 -NAGungor (Controls unexposed, disease free), 2019 1 unexposed, sick controlsunexposed, sick controls Out of scale0.25[0.06; 1.13]1416 -NAGungor (Controls unexposed, sick), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.26[0.06; 1.03]2216 -NAGungor (Controls exposed to SSRI), 2019 10.510.01.0