Mirtazapine - Medication and Pregnancy KB

Mirtazapine updated on 07-01-2025

Congenital heart defects

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18313 R77117	Chan (Controls exposed to SSRIs), 2024	Cardiac malformations	1st trimester	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.05 [0.24;4.53] ^C excluded (control group)	2/76 24/956	26	76		ref
S18314 R77120	Chan (Controls unexposed, pop general), 2024	Cardiac malformations	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.41 [0.35;5.75]	2/76 8,107/462,377	8,109	76		ref
S11838 R43454	Källen, 2013	Any cardiac defect	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: no or not specified	1.06 [0.42;2.19]	7/585 -/-	-	585		ref
					Total	2 studies	1.14 [0.56;2.32]		8,109	661
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, pop general;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18313