Mirtazapine updated on 07-01-2025

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11789
R43375		 Ozturk, 2016 Elective termination of pregnancy at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 7.46 [1.33;41.89] C 2/7   14/275 16 7
ref
S11690
R42985		 Kieler, 2015 Elective termination of pregnancy (at 12–23 weeks of gestation) during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Matched Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.60 [1.80;3.90] -/-   14,911/- - -
ref
S12913
R48979		 Winterfeld (Controls exposed to SSRI), 2015 Elective termination of pregnancy 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched Monotherapy: no or not specified 2.45 [1.22;4.89]
excluded (control group) 		28/357   12/357 40 357
ref
S12914
R48986		 Winterfeld (Controls unexposed, NOS), 2015 Elective termination of pregnancy 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 1.43 [0.79;2.60] 28/357   20/357 48 357
ref
Total 3 studies 2.29 [1.25;4.21] 64 364
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ozturk, 2016Ozturk, 2016 7.46[1.33; 41.89]16710%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Kieler, 2015Kieler, 2015 2.60[1.80; 3.90]--50%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Winterfeld (Controls unexposed, NOS), 2015Winterfeld, 2015 1 1.43[0.79; 2.60]4835739%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 57% 2.29[1.25; 4.21]643640.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.66[0.55; 12.73]6436468%NAOzturk, 2016 Winterfeld (Controls unexposed, NOS), 2015 2 case control studiescase control studies 2.60[1.77; 3.83]-- -NAKieler, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.29[1.25; 4.21]6436457%NAOzturk, 2016 Kieler, 2015 Winterfeld (Controls unexposed, NOS), 2015 3 Tags Adjustment   - No  - No 2.66[0.55; 12.73]6436468%NAOzturk, 2016 Winterfeld (Controls unexposed, NOS), 2015 2   - Yes  - Yes 2.60[1.77; 3.83]-- -NAKieler, 2015 1 MatchedMatched 2.02[1.13; 3.60]4835763%NAKieler, 2015 Winterfeld (Controls unexposed, NOS), 2015 2 Monotherapy   - no or not specified  - no or not specified 2.66[0.55; 12.73]6436468%NAOzturk, 2016 Winterfeld (Controls unexposed, NOS), 2015 2   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.60[1.77; 3.83]-- -NAKieler, 2015 1 All studiesAll studies 2.29[1.25; 4.21]6436457%NAOzturk, 2016 Kieler, 2015 Winterfeld (Controls unexposed, NOS), 2015 30.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12913

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.29[1.25; 4.21]14,96636457%NAOzturk, 2016 Kieler, 2015 Winterfeld (Controls unexposed, NOS), 2015 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.45[1.22; 4.91]40357 -NAWinterfeld (Controls exposed to SSRI), 2015 10.510.01.0