Mirtazapine updated on 07-01-2025

Macrosomia (> 4000g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12919
R49007		 Gungor (Controls exposed to SSRI), 2019 Macrosomia (a birth weight higher than 4000 g) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.48 [0.02;10.67] C
excluded (control group) 		0/16   2/40 2 16
ref
S12920
R49013		 Gungor (Controls unexposed, disease free), 2019 Macrosomia (a birth weight higher than 4000 g) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.46 [0.02;12.12] C
excluded (control group) 		0/16   1/23 1 16
ref
S12921
R49019		 Gungor (Controls unexposed, sick), 2019 Macrosomia (a birth weight higher than 4000 g) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: old history of illness/treatment (> 12 months before pregnancy) or not specified 1.45 [0.03;77.15] C 0/16   0/23 0 16
ref
Total 1 studies 1.45 [0.03;77.15] 0 16
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gungor (Controls unexposed, sick), 2019Gungor, 2019 1 1.45[0.03; 77.15]0160%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.45[0.03; 77.15]-16 -NAGungor (Controls unexposed, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.45[0.03; 77.15]-16 -NAGungor (Controls unexposed, sick), 2019 1 Tags Adjustment   - No  - No 1.45[0.03; 77.15]-16 -NAGungor (Controls unexposed, sick), 2019 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.45[0.03; 77.15]-16 -NAGungor (Controls unexposed, sick), 2019 1 Unexposed sick   - old history of illness/treatment (> ...  - old history of illness/treatment (> 12 months before pregnancy) or not specified 1.45[0.03; 77.15]-16 -NAGungor (Controls unexposed, sick), 2019 1 All studiesAll studies 1.45[0.03; 77.15]-16 -NAGungor (Controls unexposed, sick), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12919, 12920

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.46[0.02; 12.12]116 -NAGungor (Controls unexposed, disease free), 2019 1 unexposed, sick controlsunexposed, sick controls 1.45[0.03; 77.15]-16 -NAGungor (Controls unexposed, sick), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.48[0.02; 10.67]216 -NAGungor (Controls exposed to SSRI), 2019 10.510.01.0