Chlordiazepoxide updated on 02-10-2025

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17858
R75355		 Meng (Controls unexposed, sibling), 2023 Small for gestational age (birthweight below the 10th percentile for gestational age by sex) early pregnancy population based cohort retrospective sibling excluded Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 1.20 [0.76;1.88]
excluded (control group) 		-/-   -/- - -
ref
S15637
R64536		 Meng (Controls unexposed, sick), 2023 Small for gestational age (birthweight below the 10th percentile for gestational age by sex) early pregnancy population based cohort retrospective unexposed, sick Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 1.22 [0.99;1.49] 107/943   261,122/2,753,686 261,229 943
ref
Total 1 studies 1.22 [0.99;1.50] 261,229 943
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meng (Controls unexposed, sick), 2023Meng, 2023 1 1.22[0.99; 1.49]261,2299430%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.22[0.99; 1.50]261,229943 -NAMeng (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.22[0.99; 1.50]261,229943 -NAMeng (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 1.22[0.99; 1.50]261,229943 -NAMeng (Controls unexposed, sick), 2023 1 BZD Coexposure   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 1.22[0.99; 1.50]261,229943 -NAMeng (Controls unexposed, sick), 2023 1 All studiesAll studies 1.22[0.99; 1.50]261,229943 -NAMeng (Controls unexposed, sick), 2023 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17858

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.22[0.99; 1.50]261,229943 -NAMeng (Controls unexposed, sick), 2023 1 siblingssiblings 1.20[0.76; 1.89]-- -NAMeng (Controls unexposed, sibling), 2023 10.510.01.0