Lorazepam updated on 02-10-2025

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17850
R75329		 Meng a (Controls unexposed, sibling), 2023 Stillbirth (fetal death at or after 20 weeks’ gestation) early pregnancy population based cohort retrospective sibling excluded Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 1.25 [0.89;1.77]
excluded (control group) 		-/-   -/- - -
ref
S15629
R64510		 Meng a (Controls unexposed, sick), 2023 Stillbirth (fetal death at or after 20 weeks’ gestation) early pregnancy population based cohort retrospective unexposed, sick Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 1.31 [1.12;1.55] 162/11,182   30,696/2,770,460 30,858 11,182
ref
Total 1 studies 1.31 [1.11;1.54] 30,858 11,182
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meng a (Controls unexposed, sick), 2023Meng a, 2023 1 1.31[1.12; 1.55]30,85811,1820%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.31[1.11; 1.54]30,85811,182 -NAMeng a (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.31[1.11; 1.54]30,85811,182 -NAMeng a (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 1.31[1.11; 1.54]30,85811,182 -NAMeng a (Controls unexposed, sick), 2023 1 BZD Coexposure   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 1.31[1.11; 1.54]30,85811,182 -NAMeng a (Controls unexposed, sick), 2023 1 All studiesAll studies 1.31[1.11; 1.54]30,85811,182 -NAMeng a (Controls unexposed, sick), 2023 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17850

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.31[1.11; 1.54]30,85811,182 -NAMeng a (Controls unexposed, sick), 2023 1 siblingssiblings 1.25[0.89; 1.76]-- -NAMeng a (Controls unexposed, sibling), 2023 10.510.01.0