Bromazepam updated on 02-10-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15413
R63484		 Sheehy, 2019 Spontaneous abortion (6th to 19th completed week of gestation) - ICD-9 diagnosis code 634 or ICD-10 diagnosis code O03 early pregnancy nested case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Not specified Matched 2.34 [1.11;4.93] 13/39   27,136/161,415 27,149 39
ref
Total 1 studies 2.34 [1.11;4.93] 27,149 39
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Sheehy, 2019Sheehy, 2019 2.34[1.11; 4.93]27,149390%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: critical0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.34[1.11; 4.93]27,14939 -NASheehy, 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.34[1.11; 4.93]27,14939 -NASheehy, 2019 1 Tags Adjustment   - Yes  - Yes 2.34[1.11; 4.93]27,14939 -NASheehy, 2019 1 BZD Coexposure   - Not specified  - Not specified 2.34[1.11; 4.93]27,14939 -NASheehy, 2019 1 MatchedMatched 2.34[1.11; 4.93]27,14939 -NASheehy, 2019 1 All studiesAll studies 2.34[1.11; 4.93]27,14939 -NASheehy, 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.34[1.11; 4.93]27,14939 -NASheehy, 2019 10.510.01.0