Bromazepam updated on 02-10-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18589
R78989		 Kitchin, 2022 Miscarriage (ICD-9634–639 Pregnancy losses between 4-22 weeks) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Not specified Matched 1.23 [0.88;1.73] 50/158   18,020/72,121 18,070 158
ref
S15413
R63484		 Sheehy, 2019 Spontaneous abortion (6th to 19th completed week of gestation) - ICD-9 diagnosis code 634 or ICD-10 diagnosis code O03 early pregnancy nested case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Not specified Matched 2.34 [1.11;4.93] 13/39   27,136/161,415 27,149 39
ref
Total 2 studies 1.55 [0.85;2.84] 45,219 197
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kitchin, 2022Kitchin, 2022 1.23[0.88; 1.73]18,07015864%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Sheehy, 2019Sheehy, 2019 2.34[1.11; 4.93]27,1493936%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: critical Total (2 studies) I2 = 58% 1.55[0.85; 2.84]45,2191970.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.55[0.85; 2.84]45,21919758%NAKitchin, 2022 Sheehy, 2019 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.55[0.85; 2.84]45,21919758%NAKitchin, 2022 Sheehy, 2019 2 Tags Adjustment   - Yes  - Yes 1.55[0.85; 2.84]45,21919758%NAKitchin, 2022 Sheehy, 2019 2 BZD Coexposure   - Not specified  - Not specified 1.55[0.85; 2.84]45,21919758%NAKitchin, 2022 Sheehy, 2019 2 MatchedMatched 1.55[0.85; 2.84]45,21919758%NAKitchin, 2022 Sheehy, 2019 2 All studiesAll studies 1.55[0.85; 2.84]45,21919758%NAKitchin, 2022 Sheehy, 2019 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.55[0.85; 2.84]45,21919758%NAKitchin, 2022 Sheehy, 2019 20.510.01.0