Alprazolam updated on 02-10-2025

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15641
R64552		 Kelty (Controls unexposed, disease free), 2023 Admission to the special care unit during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free excluded Adjustment: No BZD Coexposure: Not specified 0.94 [0.39;2.26] C
excluded (control group) 		9/48   19/96 28 48
ref
S15642
R64557		 Kelty (Controls unexposed, sick), 2023 Admission to the special care unit during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No BZD Coexposure: Not specified 0.94 [0.39;2.26] C 9/48   19/96 28 48
ref
Total 1 studies 0.94 [0.39;2.26] 28 48
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kelty (Controls unexposed, sick), 2023Kelty, 2023 1 0.94[0.39; 2.26]28480%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.94[0.39; 2.26]2848 -NAKelty (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.94[0.39; 2.26]2848 -NAKelty (Controls unexposed, sick), 2023 1 Tags Adjustment   - No  - No 0.94[0.39; 2.26]2848 -NAKelty (Controls unexposed, sick), 2023 1 BZD Coexposure   - Not specified  - Not specified 0.94[0.39; 2.26]2848 -NAKelty (Controls unexposed, sick), 2023 1 All studiesAll studies 0.94[0.39; 2.26]2848 -NAKelty (Controls unexposed, sick), 2023 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 15641

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.94[0.39; 2.26]2848 -NAKelty (Controls unexposed, disease free), 2023 1 unexposed, sick controlsunexposed, sick controls 0.94[0.39; 2.26]2848 -NAKelty (Controls unexposed, sick), 2023 10.510.01.0