Alprazolam - Medication and Pregnancy KB

Alprazolam updated on 02-10-2025

Preterm (< 37 weeks)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17849 R75327	Meng a (Controls unexposed, sibling), 2023	Preterm birth (<37 weeks’ gestation)	early pregnancy	population based cohort retrospective	sibling excluded	Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	1.08 [0.94;1.24] excluded (control group)	-/- -/-	-	-		ref
S15628 R64508	Meng a (Controls unexposed, sick), 2023	Preterm birth (<37 weeks’ gestation)	early pregnancy	population based cohort retrospective	unexposed, sick	Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	1.19 [1.13;1.26]	1,614/14,138 274,556/2,808,074	276,170	14,138		ref
S15643 R64561	Lee, 2022	Preterm birth (< 37 weeks)	1st trimester	prospective cohort	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: Not specified	2.27 [0.92;5.60]	7/82 22/579	29	82		ref
					Total	2 studies	1.40 [0.81;2.41]		276,199	14,220
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17849