Lormetazepam updated on 02-10-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18588
R78988		 Kitchin, 2022 Miscarriage (ICD-9634–639 Pregnancy losses between 4-22 weeks) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Not specified Matched 1.33 [0.84;2.10] 28/84   18,042/72,195 18,070 84
ref
Total 1 studies 1.33 [0.84;2.10] 18,070 84
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kitchin, 2022Kitchin, 2022 1.33[0.84; 2.10]18,070840%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.33[0.84; 2.10]18,07084 -NAKitchin, 2022 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.33[0.84; 2.10]18,07084 -NAKitchin, 2022 1 Tags Adjustment   - Yes  - Yes 1.33[0.84; 2.10]18,07084 -NAKitchin, 2022 1 BZD Coexposure   - Not specified  - Not specified 1.33[0.84; 2.10]18,07084 -NAKitchin, 2022 1 MatchedMatched 1.33[0.84; 2.10]18,07084 -NAKitchin, 2022 1 All studiesAll studies 1.33[0.84; 2.10]18,07084 -NAKitchin, 2022 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.33[0.84; 2.10]18,07084 -NAKitchin, 2022 10.510.01.0