Midazolam updated on 02-10-2025

Preterm (< 37 weeks)

id	Study   Auto Meng a (Controls unexposed, sibling), 2023Meng a (Controls unexposed, sick), 2023	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17856 R75348	Meng a (Controls unexposed, sibling), 2023	Preterm birth (<37 weeks’ gestation)	early pregnancy	population based cohort retrospective	sibling excluded	Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	0.73 [0.48;1.11] excluded (control group)	-/-   -/-	-	-		ref
S15635 R64529	Meng a (Controls unexposed, sick), 2023	Preterm birth (<37 weeks’ gestation)	early pregnancy	population based cohort retrospective	unexposed, sick	Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	1.35 [1.14;1.60]	164/1,269   265,960/2,691,546	266,124	1,269		ref
					Total	1 studies	1.35 [1.14;1.60]		266,124	1,269
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 17856