Acetaminophen (Neuro-developmental outcomes) updated on 07-16-2024

Cognitive developmental disorders/delay (< 3 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16410
R67741		 Bertoldi_Pelotas, 2020 Cognitive development (Total) - INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) - Mean (SD) 2.0 (0.06) years (Acetaminophen 1st, 2nd, or 3rd trim) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No extrapolated (cont. endpoint) Paracetamol use: maternal ITW/questionnaires during pregnancy 0.91 [0.81;1.03] -/2,470   -/1,348 - 2,470
ref
S16321
R67438		 Tovo-Rodrigues, 2020 Low developmental score (< 10th percentile) - Battelle's Developmental Inventory - At 24 months during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 1.00 [0.78;1.28] -/-   -/- - -
ref
Total 2 studies 0.93 [0.83;1.03] 0 2,470
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bertoldi_Pelotas, 2020Bertoldi_Pelotas, 2020 0.91[0.81; 1.03]-2,47081%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Tovo-Rodrigues, 2020Tovo-Rodrigues, 2020 1.00[0.78; 1.28]--19%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.93[0.83; 1.03]-2,4700.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.93[0.83; 1.03]-2,4700%NABertoldi_Pelotas, 2020 Tovo-Rodrigues, 2020 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.93[0.83; 1.03]-2,4700%NABertoldi_Pelotas, 2020 Tovo-Rodrigues, 2020 2 Tags Adjustment   - No  - No 0.91[0.81; 1.03]-2,470 -NABertoldi_Pelotas, 2020 1   - Yes  - Yes 1.00[0.78; 1.28]-- -NATovo-Rodrigues, 2020 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 0.91[0.81; 1.03]-2,470 -NABertoldi_Pelotas, 2020 1 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 1.00[0.78; 1.28]-- -NATovo-Rodrigues, 2020 1   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 0.91[0.81; 1.03]-2,470 -NABertoldi_Pelotas, 2020 1 All studiesAll studies 0.93[0.83; 1.03]-2,4700%NABertoldi_Pelotas, 2020 Tovo-Rodrigues, 2020 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.93[0.83; 1.03]-2,4700%NABertoldi_Pelotas, 2020 Tovo-Rodrigues, 2020 20.510.01.0