Perampanel (Epilepsy) updated on 04-22-2025

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17200
R72078		 The Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls exposed to Lamotrigine), 2024 Major congenital malformations 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 10.78 [0.30;390.33] C
excluded (control group) 		0/2   1/50 1 2
ref
S17201
R72080		 The Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls unexposed, sick), 2024 Major congenital malformations 1st trimester prospective cohort unexposed, sick Adjustment: No 6.54 [0.26;166.65] C 0/2   16/340 16 2
ref
S17223
R72124		 The West China Registry (Epilepsy) (Controls exposed to LTG), 2024 Major congenital malformation during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 15.00 [0.24;926.88] C
excluded (control group) 		0/3   0/38 0 3
ref
S17224
R72126		 The West China Registry (Epilepsy) (Controls unexposed, sick), 2024 Major congenital malformation during pregnancy (anytime or not specified) excluded prospective cohort unexposed, sick Adjustment: No 6.55 [0.29;148.57] C
excluded (exposition period) 		0/3   7/253 7 3
ref
Total 1 studies 6.54 [0.26;166.65] 16 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF The Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls unexposed, sick), 2024The Kerala Registry for Epile..., 2024 1 6.54[0.26; 166.65]1620%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 6.54[0.26; 166.65]162 -NAThe Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls unexposed, sick), 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 6.54[0.26; 166.65]162 -NAThe Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls unexposed, sick), 2024 1 Tags Adjustment   - No  - No 6.54[0.26; 166.65]162 -NAThe Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls unexposed, sick), 2024 1 All studiesAll studies 6.54[0.26; 166.65]162 -NAThe Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls unexposed, sick), 2024 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17200, 17223

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 6.54[0.26; 166.65]162 -NAThe Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls unexposed, sick), 2024 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale10.78[0.30; 390.33]12 -NAThe Kerala Registry for Epilepsy and Pregnancy (Epilepsy) (Controls exposed to Lamotrigine), 2024 10.510.01.0