Brivaracetam (Epilepsy) updated on 04-22-2025

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17167
R71987		 Battino (Epilepsy), 2024 Major congenital malformations (MCMs) early pregnancy prospective cohort exposed to other treatment, sick Adjustment: No 10.48 [0.42;258.67] C 0/2   110/3,584 110 2
ref
Total 1 studies 10.48 [0.42;258.67] 110 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Battino (Epilepsy), 2024Battino, 2024 1 10.48[0.42; 258.67]11020%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 10.48[0.42; 258.67]1102 -NABattino (Epilepsy), 2024 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 10.48[0.42; 258.67]1102 -NABattino (Epilepsy), 2024 1 Tags Adjustment   - No  - No 10.48[0.42; 258.67]1102 -NABattino (Epilepsy), 2024 1 All studiesAll studies 10.48[0.42; 258.67]1102 -NABattino (Epilepsy), 2024 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale10.48[0.42; 258.67]1102 -NABattino (Epilepsy), 2024 10.510.01.0