Cenobamate (Mixed indications = All indications) - Medication and Pregnancy KB

Cenobamate (Mixed indications = All indications) updated on 04-22-2025

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17170 R71993	The NAAED (Indications NOS) (Controls exposed to LTG), 2024	Major congenital malformations	1st trimester	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	15.29 [0.62;379.81] ^C excluded (control group)	0/2 52/2,461	52	2		ref
S17171 R71995	The NAAED (Indications NOS) (Controls unexposed, disease free), 2024	Major congenital malformations	1st trimester	prospective cohort	unexposed, disease free	Adjustment: No	27.86 [1.09;711.10] ^C	0/2 15/1,311	15	2		ref
					Total	1 studies	27.86 [1.09;711.10]		15	2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Indications NOS) (Controls unexposed, disease free;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17170