Glucagon-like peptide-1 (GLP-1) receptor agonists

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18782
R79927		 Maya, 2025 Hypertensive disorders of pregnancy 3 months or more before pregnancy or1st trimester excluded retrospective cohort unexposed (general population or NOS) Adjustment: Yes GLP1-RA indication: Mixed (Diabetes and/or Overweight) or Unspecified Matched 1.15 [1.00;1.32]
excluded (exposition period) 		200/432   465/1,296 665 432
ref
S18788
R79969		 Pondugula, 2025 Hypertensive disorders of pregnancy (gestational hypertension, preeclampsia with or without severe features, superimposed preeclampsia, eclampsia, or HELLP syndrome) early pregnancy retrospective cohort unexposed, sick Adjustment: Yes GLP1-RA indication: Overweight/Obesity 0.47 [0.25;0.89] 21/90   75/200 96 90
ref
Total 1 studies 0.47 [0.25;0.89] 96 90
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pondugula, 2025Pondugula, 2025 0.47[0.25; 0.89]96900%ROB confusion: seriousROB selection: unclearROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.47[0.25; 0.89]9690 -NAPondugula, 2025 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.47[0.25; 0.89]9690 -NAPondugula, 2025 1 Tags Adjustment   - Yes  - Yes 0.47[0.25; 0.89]9690 -NAPondugula, 2025 1 GLP1-RA indication   - Overweight/Obesity  - Overweight/Obesity 0.47[0.25; 0.89]9690 -NAPondugula, 2025 1 All studiesAll studies 0.47[0.25; 0.89]9690 -NAPondugula, 2025 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.47[0.25; 0.89]9690 -NAPondugula, 2025 10.510.01.0