Glucagon-like peptide-1 (GLP-1) receptor agonists - Medication and Pregnancy KB

Glucagon-like peptide-1 (GLP-1) receptor agonists

Neonatal hypoglycemia

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18794 R79988	Kolding - Semaglutide (Controls exposed to insulin), 2025	Hypoglycemia of registered livebirths	1st trimester	retrospective cohort	exposed to other treatment, sick excluded	Adjustment: No GLP1-RA indication: Mixed (Diabetes and/or Overweight) or Unspecified	0.62 [0.12;2.10] excluded (control group)	3/29 88/517	91	29		ref
S18796 R79995	Kolding - Semaglutide (Controls unexposed, general pop), 2025	Hypoglycemia of registered livebirths	1st trimester	retrospective cohort	unexposed (general population or NOS)	Adjustment: No GLP1-RA indication: Mixed (Diabetes and/or Overweight) or Unspecified	7.89 [1.53;25.78]	3/29 1,448/100,448	1,451	29		ref
					Total	1 studies	7.89 [1.92;32.39]		1,451	29
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, general pop;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18794