Glucagon-like peptide-1 (GLP-1) receptor agonists

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18788
R79974		 Pondugula, 2025 Fetal death (as opposed to neonatal death or live birth) early pregnancy retrospective cohort unexposed, sick Adjustment: No GLP1-RA indication: Overweight/Obesity 6.86 [0.70;66.90] C 3/90   1/200 4 90
ref
Total 1 studies 6.86 [0.70;66.90] 4 90
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pondugula, 2025Pondugula, 2025 6.86[0.70; 66.90]4900%ROB confusion: seriousROB selection: unclearROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 6.86[0.70; 66.90]490 -NAPondugula, 2025 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 6.86[0.70; 66.90]490 -NAPondugula, 2025 1 Tags Adjustment   - No  - No 6.86[0.70; 66.90]490 -NAPondugula, 2025 1 GLP1-RA indication   - Overweight/Obesity  - Overweight/Obesity 6.86[0.70; 66.90]490 -NAPondugula, 2025 1 All studiesAll studies 6.86[0.70; 66.90]490 -NAPondugula, 2025 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 6.86[0.70; 66.90]490 -NAPondugula, 2025 10.510.01.0