Glucagon-like peptide-1 (GLP-1) receptor agonists - Medication and Pregnancy KB

Glucagon-like peptide-1 (GLP-1) receptor agonists

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18797 R80002	Chou, 2025	Stillbirth (foetal death at or after 20 completed weeks of gestation)	1st trimester	population based cohort retrospective	exposed to other treatment, sick	Adjustment: No GLP1-RA indication: Type 2 diabetes (T2D)	1.09 [0.23;5.26]	2/68 7/260	9	68		ref
S18768 R79859	Dao (Controls exposed to metformin/insulin), 2024	Stillbirth (≥22 weeks)	1st trimester	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No GLP1-RA indication: Mixed (Diabetes and/or Overweight) or Unspecified	1.12 [0.07;18.04] ^C excluded (control group)	1/114 1/127	2	114		ref
S18806 R80015	Dao (Controls unexposed, sick), 2024	Stillbirth (≥22 weeks)	1st trimester	prospective cohort	unexposed, sick	Adjustment: No GLP1-RA indication: Mixed (Diabetes and/or Overweight) or Unspecified	0.26 [0.03;2.35] ^C	1/114 4/121	5	114		ref
					Total	2 studies	0.66 [0.17;2.53]		14	182
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18768

Umbrella review (other published meta-analyses)