Glucagon-like peptide-1 (GLP-1) receptor agonists - Medication and Pregnancy KB

Glucagon-like peptide-1 (GLP-1) receptor agonists

Elective/induced termination of pregnancy

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18768 R79863	Dao (Controls exposed to metformin/insulin), 2024	Pregnancy termination (Elective or medical termination of pregnancy)	1st trimester	prospective cohort	exposed to other treatment, sick excluded	Adjustment: Yes GLP1-RA indication: Mixed (Diabetes and/or Overweight) or Unspecified	3.89 [1.48;10.20] excluded (control group)	23/168 6/156	29	168		ref
S18806 R80019	Dao (Controls unexposed, sick), 2024	Pregnancy termination (Elective or medical termination of pregnancy)	1st trimester	prospective cohort	unexposed, sick	Adjustment: Yes GLP1-RA indication: Mixed (Diabetes and/or Overweight) or Unspecified	1.39 [0.66;2.93]	23/168 13/163	36	168		ref
					Total	1 studies	1.39 [0.66;2.93]		36	168
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18768