Glucagon-like peptide-1 (GLP-1) receptor agonists - Medication and Pregnancy KB

Glucagon-like peptide-1 (GLP-1) receptor agonists

Therapeutic terminations of pregnancy

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18768 R79857	Dao (Controls exposed to metformin/insulin), 2024	Medical termination of pregnancy	1st trimester	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No GLP1-RA indication: Mixed (Diabetes and/or Overweight) or Unspecified	3.34 [0.34;32.59] ^C excluded (control group)	3/117 1/128	4	117		ref
S18806 R80013	Dao (Controls unexposed, sick), 2024	Medical termination of pregnancy	1st trimester	prospective cohort	unexposed, sick	Adjustment: No GLP1-RA indication: Mixed (Diabetes and/or Overweight) or Unspecified	0.45 [0.11;1.80] ^C	3/117 7/128	10	117		ref
					Total	1 studies	0.45 [0.11;1.80]		10	117
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18768