Elexacaftor, tezacaftor and ivacaftor (ETI)

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S19220
R81477		 Etherington, 2024 Gestational diabetes mellitus (GDM) at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 3.89 [1.19;12.68] C 17/24   10/26 27 24
ref
Total 1 studies 3.89 [1.19;12.68] 27 24
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Etherington, 2024Etherington, 2024 3.89[1.19; 12.68]27240%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: unclear0.910.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.89[1.19; 12.68]2724 -NAEtherington, 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.89[1.19; 12.68]2724 -NAEtherington, 2024 1 Tags Adjustment   - No  - No 3.89[1.19; 12.68]2724 -NAEtherington, 2024 1 All studiesAll studies 3.89[1.19; 12.68]2724 -NAEtherington, 2024 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 3.89[1.19; 12.68]2724 -NAEtherington, 2024 10.510.01.0