Elexacaftor, tezacaftor and ivacaftor (ETI)

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S19220
R81478		 Etherington, 2024 Preterm birth during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 0.31 [0.09;1.05] C 5/26   13/30 18 26
ref
Total 1 studies 0.31 [0.09;1.05] 18 26
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Etherington, 2024Etherington, 2024 0.31[0.09; 1.05]18260%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: unclear0.22.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.31[0.09; 1.05]1826 -NAEtherington, 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.31[0.09; 1.05]1826 -NAEtherington, 2024 1 Tags Adjustment   - No  - No 0.31[0.09; 1.05]1826 -NAEtherington, 2024 1 All studiesAll studies 0.31[0.09; 1.05]1826 -NAEtherington, 2024 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.31[0.09; 1.05]1826 -NAEtherington, 2024 10.510.01.0