Fluconazole (all routes except local only) - Cumulative dose > 150 mg updated on 01-29-2025

Polydactyly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17830
R75211		 Molgaard-Nielsen (300 - 6000mg), 2013 Polydactyly 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 2.71 [1.01;7.27] 4/2,252   -/968,236 - 2,252
ref
Total 1 studies 2.71 [1.01;7.27] 0 2,252
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Molgaard-Nielsen (300 - 6000mg), 2013Molgaard-Nielsen, 2013 1 2.71[1.01; 7.27]-2,2520%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: 300 - 6000mg;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.71[1.01; 7.27]-2,252 -NAMolgaard-Nielsen (300 - 6000mg), 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.71[1.01; 7.27]-2,252 -NAMolgaard-Nielsen (300 - 6000mg), 2013 1 Tags Adjustment   - Yes  - Yes 2.71[1.01; 7.27]-2,252 -NAMolgaard-Nielsen (300 - 6000mg), 2013 1 All studiesAll studies 2.71[1.01; 7.27]-2,252 -NAMolgaard-Nielsen (300 - 6000mg), 2013 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.71[1.01; 7.27]-2,252 -NAMolgaard-Nielsen (300 - 6000mg), 2013 10.510.01.0