Fluconazole (all routes except local only) - Cumulative dose > 150 mg updated on 01-29-2025

Urinary malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17646
R74526		 Berard (> 150 mg), 2019 Urinary malformations 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes 1.41 [0.62;3.23] 6/400   2,197/226,199 2,203 400
ref
Total 1 studies 1.41 [0.62;3.22] 2,203 400
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Berard (> 150 mg), 2019Berard, 2019 1 1.41[0.62; 3.23]2,2034000%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: > 150 mg;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.41[0.62; 3.22]2,203400 -NABerard (> 150 mg), 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.41[0.62; 3.22]2,203400 -NABerard (> 150 mg), 2019 1 Tags Adjustment   - Yes  - Yes 1.41[0.62; 3.22]2,203400 -NABerard (> 150 mg), 2019 1 All studiesAll studies 1.41[0.62; 3.22]2,203400 -NABerard (> 150 mg), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.41[0.62; 3.22]2,203400 -NABerard (> 150 mg), 2019 10.510.01.0