Fluconazole (all routes except local only) - Cumulative dose > 150 mg updated on 01-29-2025

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17646
R74525		 Berard (> 150 mg), 2019 Genital malformations 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes 2.30 [0.94;5.62] 5/400   1,174/226,199 1,179 400
ref
Total 1 studies 2.30 [0.94;5.62] 1,179 400
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Berard (> 150 mg), 2019Berard, 2019 1 2.30[0.94; 5.62]1,1794000%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: > 150 mg;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.30[0.94; 5.62]1,179400 -NABerard (> 150 mg), 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.30[0.94; 5.62]1,179400 -NABerard (> 150 mg), 2019 1 Tags Adjustment   - Yes  - Yes 2.30[0.94; 5.62]1,179400 -NABerard (> 150 mg), 2019 1 All studiesAll studies 2.30[0.94; 5.62]1,179400 -NABerard (> 150 mg), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.30[0.94; 5.62]1,179400 -NABerard (> 150 mg), 2019 10.510.01.0