Fluconazole (all routes except local only) - Cumulative dose > 150 mg updated on 01-29-2025

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17646
R74519		 Berard (> 150 mg), 2019 Stillbirth (fetal deaths with a birth weight of ≥ 500 g or ≥ 20 weeks of gestation) during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Matched 0.57 [0.07;4.50] 1/13   711/7,819 712 13
ref
S17832
R75255		 Pasternak (>300 mg), 2018 Stillbirth (fetal loss after 22 or 28 completed weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose Matched 0.70 [0.39;1.26] 12/4,543   387/106,690 399 4,543
ref
S17652
R74567		 Molgaard-Nielsen (> 350-5600), 2016 Stillbirth (pregnancy loss from 23 weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Matched 4.10 [1.89;8.90] 7/597   77/21,506 84 597
ref
Total 3 studies 1.31 [0.32;5.34] 1,195 5,153
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Berard (> 150 mg), 2019Berard, 2019 1 0.57[0.07; 4.50]7121322%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Pasternak (>300 mg), 2018Pasternak, 2018 2 0.70[0.39; 1.26]3994,54340%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Molgaard-Nielsen (> 350-5600), 2016Molgaard-Nielsen, 2016 3 4.10[1.89; 8.90]8459738%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 85% 1.31[0.32; 5.34]1,1955,1530.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: > 150 mg; 2: >300 mg; 3: > 350-5600;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.66[0.29; 9.40]4835,14092%NAPasternak (>300 mg), 2018 Molgaard-Nielsen (> 350-5600), 2016 2 case control studiescase control studies 0.57[0.07; 4.57]71213 -NABerard (> 150 mg), 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.31[0.32; 5.34]1,1955,15385%NABerard (> 150 mg), 2019 Pasternak (>300 mg), 2018 Molgaard-Nielsen (> 350-5600), 2016 3 Tags Adjustment   - Yes  - Yes 1.31[0.32; 5.34]1,1955,15385%NABerard (> 150 mg), 2019 Pasternak (>300 mg), 2018 Molgaard-Nielsen (> 350-5600), 2016 3 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 0.70[0.39; 1.26]3994,543 -NAPasternak (>300 mg), 2018 1 MatchedMatched 1.31[0.32; 5.34]1,1955,15385%NABerard (> 150 mg), 2019 Pasternak (>300 mg), 2018 Molgaard-Nielsen (> 350-5600), 2016 3 All studiesAll studies 1.31[0.32; 5.34]1,1955,15385%NABerard (> 150 mg), 2019 Pasternak (>300 mg), 2018 Molgaard-Nielsen (> 350-5600), 2016 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.31[0.32; 5.34]1,1955,15385%NABerard (> 150 mg), 2019 Pasternak (>300 mg), 2018 Molgaard-Nielsen (> 350-5600), 2016 30.510.01.0