Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Postpartum hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13958
R54683
Ersboll - Beta-blockers (Controls unexposed, disease free), 2014 Postpartum haemorrhage during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free excluded Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) Matched 0.91 [0.21;3.93] C
excluded (control group)
2/51   27/627 29 51
ref
S13957
R54672
Ersboll - Beta-blockers (Controls unexposed, sick), 2014 Postpartum haemorrhage during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 0.80 [0.16;4.12] C 2/51   6/124 8 51
ref
Total 1 studies 0.80 [0.16;4.12] 8 51
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ersboll - Beta-blockers (Controls unexposed, sick), 2014Ersboll - Beta-blockers, 2014 1 0.80[0.16; 4.12]8510%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.80[0.16; 4.12]851 -NAErsboll - Beta-blockers (Controls unexposed, sick), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.80[0.16; 4.12]851 -NAErsboll - Beta-blockers (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 0.80[0.16; 4.12]851 -NAErsboll - Beta-blockers (Controls unexposed, sick), 2014 1 Indications Antihypertensive   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 0.80[0.16; 4.12]851 -NAErsboll - Beta-blockers (Controls unexposed, sick), 2014 1 All studiesAll studies 0.80[0.16; 4.12]851 -NAErsboll - Beta-blockers (Controls unexposed, sick), 2014 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13958

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.91[0.21; 3.93]2951 -NAErsboll - Beta-blockers (Controls unexposed, disease free), 2014 1 unexposed, sick controlsunexposed, sick controls 0.80[0.16; 4.12]851 -NAErsboll - Beta-blockers (Controls unexposed, sick), 2014 10.510.01.0