Beta-blockers (All routes except ocular) (versus unexposed) - Medication and Pregnancy KB

Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Cleft palate

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13907 R54452	Bergman - Beta-blockers, 2018	Cleft palate	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	1.70 [0.90;3.40]	10/150 1,998/52,567	2,008	150		ref
S13785 R53987	Fisher a - Beta-blockers, 2018	Cleft palate only	1st trimester	case control	unexposed, disease free	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	0.90 [0.40;2.10]	7/- 1,439/-	1,446	-		ref
S13416 R51620	Puho - Metoprolol, 2007	Posterior cleft palate	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	2.10 [0.80;5.70]	4/124 597/38,628	601	124		ref
					Total	3 studies	1.47 [0.92;2.33]		4,055	274
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded