Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Oesophageal atresia with or without tracheo-oesophageal fistula

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13907
R54465
Bergman - Beta-blockers, 2018 Oesophageal atresia with or without tracheo-oesophageal fistula 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 1.10 [0.30;3.50] 3/-   747/- 750 -
ref
S13785
R53990
Fisher a - Beta-blockers, 2018 Esophageal atresia 1st trimester case control unexposed, disease free Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 1.30 [0.30;3.50] 4/-   657/- 661 -
ref
Total 2 studies 1.20 [0.50;2.85] 1,411 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bergman - Beta-blockers, 2018Bergman - Beta-blockers, 2018 1.10[0.30; 3.50]750-50%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Fisher a - Beta-blockers, 2018Fisher a - Beta-blockers, 2018 1.30[0.30; 3.50]661-50%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 1.20[0.50; 2.85]1,411-0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.20[0.50; 2.85]1,411-0%NABergman - Beta-blockers, 2018 Fisher a - Beta-blockers, 2018 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[0.50; 2.85]1,411-0%NABergman - Beta-blockers, 2018 Fisher a - Beta-blockers, 2018 2 Tags Adjustment   - No  - No 1.30[0.38; 4.44]661- -NAFisher a - Beta-blockers, 2018 1   - Yes  - Yes 1.10[0.32; 3.76]750- -NABergman - Beta-blockers, 2018 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.20[0.50; 2.85]1,411-0%NABergman - Beta-blockers, 2018 Fisher a - Beta-blockers, 2018 2 All studiesAll studies 1.20[0.50; 2.85]1,411-0%NABergman - Beta-blockers, 2018 Fisher a - Beta-blockers, 2018 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[0.50; 2.85]1,411-0%NABergman - Beta-blockers, 2018 Fisher a - Beta-blockers, 2018 20.510.01.0