Beta-blockers (All routes except ocular) (versus unexposed) - Medication and Pregnancy KB

Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Coarctation of aorta

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13901 R54398	Duan - Beta-blockers, 2017	Coarctation	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	1.20 [0.30;4.30]	5/2,628 218/374,391	223	2,628		ref
S13888 R55952	Fisher - Beta-blockers (Controls unexposed, disease free), 2017	Coarctation of the aorta	early pregnancy	case control	unexposed, disease free excluded	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	2.61 [1.25;5.45] excluded (control group)	9/49 -/-	-	49		ref
S14244 R55964	Fisher - Beta-blockers (Controls unexposed, sick), 2017	Coarctation of the aorta	early pregnancy	case control	unexposed, sick	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	1.95 [0.88;4.32]	9/49 -/-	-	49		ref
					Total	2 studies	1.72 [0.87;3.40]		223	2,677
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13888