Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Atresia or stenosis of other parts of small intestine

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13907
R54466
Bergman - Beta-blockers, 2018 Atresia or stenosis of other parts of small intestine 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 1.90 [0.60;6.20] 3/-   423/- 426 -
ref
S13785
R53991
Fisher a - Beta-blockers, 2018 Small intestinal atresia/stenosis 1st trimester case control unexposed, disease free Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 2.90 [1.10;7.50] 6/-   420/- 426 -
ref
Total 2 studies 2.45 [1.17;5.13] 852 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bergman - Beta-blockers, 2018Bergman - Beta-blockers, 2018 1.90[0.60; 6.20]426-40%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Fisher a - Beta-blockers, 2018Fisher a - Beta-blockers, 2018 2.90[1.10; 7.50]426-60%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 2.45[1.17; 5.13]852-0.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.45[1.17; 5.13]852-0%NABergman - Beta-blockers, 2018 Fisher a - Beta-blockers, 2018 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.45[1.17; 5.13]852-0%NABergman - Beta-blockers, 2018 Fisher a - Beta-blockers, 2018 2 Tags Adjustment   - Yes  - Yes 2.45[1.17; 5.13]852-0%NABergman - Beta-blockers, 2018 Fisher a - Beta-blockers, 2018 2 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.45[1.17; 5.13]852-0%NABergman - Beta-blockers, 2018 Fisher a - Beta-blockers, 2018 2 All studiesAll studies 2.45[1.17; 5.13]852-0%NABergman - Beta-blockers, 2018 Fisher a - Beta-blockers, 2018 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.45[1.17; 5.13]852-0%NABergman - Beta-blockers, 2018 Fisher a - Beta-blockers, 2018 20.510.01.0