Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Congenital constriction bands/amniotic band

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13889
R54334
Syvanen - Beta-blockers, 2021 Congenital limb deficiencies due to amniotic bands 1st trimester nested case control unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 24.20 [2.57;228.20] 4/5   102/631 106 5
ref
Total 1 studies 24.20 [2.57;228.04] 106 5
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Syvanen - Beta-blockers, 2021Syvanen - Beta-blockers, 2021 24.20[2.57; 228.20]10650%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 24.20[2.57; 228.04]1065 -NASyvanen - Beta-blockers, 2021 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 24.20[2.57; 228.04]1065 -NASyvanen - Beta-blockers, 2021 1 Tags Adjustment   - Yes  - Yes 24.20[2.57; 228.04]1065 -NASyvanen - Beta-blockers, 2021 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 24.20[2.57; 228.04]1065 -NASyvanen - Beta-blockers, 2021 1 All studiesAll studies 24.20[2.57; 228.04]1065 -NASyvanen - Beta-blockers, 2021 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale24.20[2.57; 228.04]1065 -NASyvanen - Beta-blockers, 2021 10.510.01.0