Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Abruptio placentae (retroplacental hematoma)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14051
R55679		 Xiang - Labetalol, 2020 Placental abruption during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication 0.27 [0.13;0.59] C 10/127   30/126 40 127
ref
S13957
R54670		 Ersboll - Beta-blockers (Controls unexposed, sick), 2014 Placental abruption during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 0.81 [0.03;20.18] C 0/51   1/124 1 51
ref
Total 2 studies 0.29 [0.14;0.61] 41 178
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Xiang - Labetalol, 2020Xiang - Labetalol, 2020 0.27[0.13; 0.59]4012795%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Ersboll - Beta-blockers (Controls unexposed, sick), 2014Ersboll - Beta-blockers, 2014 1 0.81[0.03; 20.18]1515%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.29[0.14; 0.61]411780.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.81[0.03; 20.18]151 -NAErsboll - Beta-blockers (Controls unexposed, sick), 2014 1 case control studiescase control studies 0 RCTRCT 0.27[0.13; 0.59]40127 -NAXiang - Labetalol, 2020 1 Type of controls unexposed, sickunexposed, sick 0.29[0.14; 0.61]411780%NAXiang - Labetalol, 2020 Ersboll - Beta-blockers (Controls unexposed, sick), 2014 2 Tags Adjustment   - No  - No 0.81[0.03; 20.18]151 -NAErsboll - Beta-blockers (Controls unexposed, sick), 2014 1   - Randomisation  - Randomisation 0.27[0.13; 0.59]40127 -NAXiang - Labetalol, 2020 1 Indications Antihypertensive   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 0.81[0.03; 20.18]151 -NAErsboll - Beta-blockers (Controls unexposed, sick), 2014 1   - Only chronic hypertension indication  - Only chronic hypertension indication 0.27[0.13; 0.59]40127 -NAXiang - Labetalol, 2020 1 All studiesAll studies 0.29[0.14; 0.61]411780%NAXiang - Labetalol, 2020 Ersboll - Beta-blockers (Controls unexposed, sick), 2014 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.29[0.14; 0.61]411780%NAXiang - Labetalol, 2020 Ersboll - Beta-blockers (Controls unexposed, sick), 2014 20.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Magee (Placental abruption)Magee (Placental abruption) 2.01[0.61; 6.64]0%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT6 Bellos - Labetalol (Placental abruption (Rand ...Bellos - Labetalol (Placental abruption (Randomized controlled trial and Cohort studies)) Out of scale0.49[0.10; 2.41]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos - Labetalol (Placental abruption (Rand ...Bellos - Labetalol (Placental abruption (Randomized controlled trial only)) Out of scale0.49[0.10; 2.41]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Abalos (Placental abruption (RCT versus no an ...Abalos (Placental abruption (RCT versus no antihypertensive drugs/placebo)) 5.11[0.25; 104.96]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT3 metaPregmetaPreg Out of scale0.29[0.14; 0.61]0%178----Xiang - Labetalol, 2020 Ersboll - Beta-blockers (Controls unexposed, sick), 2014 20.510.01.0