Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Maternal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14051
R55681		 Xiang - Labetalol, 2020 Maternal mortality during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication 0.99 [0.02;50.39] C 0/127   0/126 0 127
ref
Total 1 studies 0.99 [0.02;50.39] 0 127
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Xiang - Labetalol, 2020Xiang - Labetalol, 2020 0.99[0.02; 50.39]01270%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 0.99[0.02; 50.39]-127 -NAXiang - Labetalol, 2020 1 Type of controls unexposed, sickunexposed, sick 0.99[0.02; 50.39]-127 -NAXiang - Labetalol, 2020 1 Tags Adjustment   - Randomisation  - Randomisation 0.99[0.02; 50.39]-127 -NAXiang - Labetalol, 2020 1 Indications Antihypertensive   - Only chronic hypertension indication  - Only chronic hypertension indication 0.99[0.02; 50.39]-127 -NAXiang - Labetalol, 2020 1 All studiesAll studies 0.99[0.02; 50.39]-127 -NAXiang - Labetalol, 2020 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.99[0.02; 50.39]-127 -NAXiang - Labetalol, 2020 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Magee (Maternal death)Magee (Maternal death) 2.92[0.12; 70.68]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT1 metaPregmetaPreg 0.99[0.02; 50.39]NaN%127----Xiang - Labetalol, 2020 10.510.01.0