Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Child/Infant death (> 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14079
R55428		 Gandjbakhch - Beta-blockers, 2018 Child sudden cardiac death during follow-up (until age of 25) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 0.69 [0.07;6.78] C 1/13   4/37 5 13
ref
Total 1 studies 0.69 [0.07;6.78] 5 13
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gandjbakhch - Beta-blockers, 2018Gandjbakhch - Beta-blockers, 2018 0.69[0.07; 6.78]5130%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.69[0.07; 6.78]513 -NAGandjbakhch - Beta-blockers, 2018 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.69[0.07; 6.78]513 -NAGandjbakhch - Beta-blockers, 2018 1 Tags Adjustment   - No  - No 0.69[0.07; 6.78]513 -NAGandjbakhch - Beta-blockers, 2018 1 Indications Antihypertensive   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 0.69[0.07; 6.78]513 -NAGandjbakhch - Beta-blockers, 2018 1 All studiesAll studies 0.69[0.07; 6.78]513 -NAGandjbakhch - Beta-blockers, 2018 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.69[0.07; 6.78]513 -NAGandjbakhch - Beta-blockers, 2018 10.510.01.0