Beta-blockers (All routes except ocular) (versus unexposed) - Medication and Pregnancy KB

Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Neonatal hypoglycemia

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13853 R54282	Kayser - Metoprolol/bisoprolol, 2020	Neonatal hypoglycaemia (blood glucose levels < 35mg/dl at day 1 or 45 mg/dl after)	days before delivery	prospective cohort	unexposed, disease free	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	1.00 [0.40;2.80]	7/252 13/588	20	252		ref
S13854 R54331	Kumar - Beta-blockers, 2020	Hypoglycemia (at least 1 point of care (POC) glucose <40 mg/dL within 24 hours of life)	during pregnancy (anytime or not specified)	retrospective cohort	unexposed, disease free	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	1.75 [1.18;2.60]	78/228 914/4,103	992	228		ref
S14051 R55686	Xiang - Labetalol, 2020	Neonatal hypoglycemia (low plasma glucose levels 30 mg/dL within 24 hours after the birth)	during pregnancy (anytime or not specified)	randomized controlled trial	unexposed, sick	Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication	2.00 [0.49;8.19] ^C	6/124 3/121	9	124		ref
S13863 R54239	Mazkereth - Beta-blockers, 2019	Neonatal hypoglycemia	during pregnancy (anytime or not specified)	retrospective cohort	unexposed, sick	Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched	1.98 [1.16;3.38] ^C	47/153 28/153	75	153		ref
S13795 R54103	Bateman - Beta-blockers, 2016	Neonatal hypoglycemia (ICD-9 775.6)	late pregnancy	retrospective cohort (claims database)	unexposed, sick	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	1.68 [1.50;1.89]	459/10,561 834/31,683	1,293	10,561		ref
S13957 R54668	Ersboll - Beta-blockers (Controls unexposed, sick), 2014	Neonatal hypoglycaemia	during pregnancy (anytime or not specified)	retrospective cohort	unexposed, sick	Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...)	29.86 [1.62;550.83] ^C	5/51 0/124	5	51		ref
S13846 R54256	Darcie - Atenolol, 2004	Newborns with hypoglycemia (blood glycemia less than 40 mg/dL)	late pregnancy	prospective cohort	unexposed, sick	Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified	4.64 [1.23;17.54] ^C	26/40 4/14	30	40		ref
S14183 R55599	Yassen - Acebutolol, 1992	Neonatal hypoglycaemia (< 2.2 mmol/l)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, disease free	Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched	5.71 [0.52;62.66] ^C	4/11 1/11	5	11		ref
S14027 R55132	Rosenfeld - Pindolol, 1986	Neonatal hypoglycaemia (< 30mg%)	during pregnancy (anytime or not specified)	randomized controlled trial	unexposed, sick	Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified	0.45 [0.04;5.40] ^C	1/23 2/22	3	23		ref
					Total	9 studies	1.77 [1.43;2.19]		2,432	11,443
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Asymetry test p-value = 0.2966 (by Egger's regression)

slope=0.4845 (0.0730); intercept=0.5029 (0.4459); t=1.1277; p=0.2966

p values plot

Sub-groups analysis using all included studies

excluded

Umbrella review (other published meta-analyses)