Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Neonatal intracranial hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13883
R54318		 Thewissen - Labetalol (Controls unexposed, disease free), 2017 Large intraventricular haemorrhage (>= grade 3) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 5.51 [0.25;122.09] C
excluded (control group) 		2/22   0/22 2 22
ref
S13866
R54315		 Thewissen - Labetalol (Controls unexposed, sick), 2017 Large intraventricular haemorrhage (>= grade 3) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 1.00 [0.13;7.81] C 2/22   2/22 4 22
ref
Total 1 studies 1.00 [0.13;7.81] 4 22
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Thewissen - Labetalol (Controls unexposed, sick), 2017Thewissen - Labetalol, 2017 1 1.00[0.13; 7.81]4220%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.52.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.00[0.13; 7.81]422 -NAThewissen - Labetalol (Controls unexposed, sick), 2017 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.00[0.13; 7.81]422 -NAThewissen - Labetalol (Controls unexposed, sick), 2017 1 Tags Adjustment   - No  - No 1.00[0.13; 7.81]422 -NAThewissen - Labetalol (Controls unexposed, sick), 2017 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.00[0.13; 7.81]422 -NAThewissen - Labetalol (Controls unexposed, sick), 2017 1 MatchedMatched 1.00[0.13; 7.81]422 -NAThewissen - Labetalol (Controls unexposed, sick), 2017 1 All studiesAll studies 1.00[0.13; 7.81]422 -NAThewissen - Labetalol (Controls unexposed, sick), 2017 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13883

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.51[0.25; 122.09]222 -NAThewissen - Labetalol (Controls unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls 1.00[0.13; 7.81]422 -NAThewissen - Labetalol (Controls unexposed, sick), 2017 10.510.01.0