Beta-blockers (All routes except ocular) (versus unexposed) - Medication and Pregnancy KB

Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Nervous system anomalies

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17127 R71759	Delteil - Beta-blockers, 2024	Nervous system malformations	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No Indications Antihypertensive: Only chronic indication (hypertension or cardiac)	0.88 [0.22;3.53] ^C	2/974 387/165,775	389	974		ref
S13791 R54091	Bateman_USMAX - Beta-blockers, 2018	Central nervous system malformations	1st trimester	retrospective cohort (claims database)	unexposed, sick	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	1.37 [0.58;3.25]	-/1,668 36/13,232	-	1,668		ref
					Total	2 studies	1.21 [0.58;2.52]		389	2,642
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Umbrella review (other published meta-analyses)