Beta-blockers (All routes except ocular) (versus unexposed) - Medication and Pregnancy KB

Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Oro-facial clefts

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17127 R71762	Delteil - Beta-blockers, 2024	Oro-facial Clefts	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No Indications Antihypertensive: Only chronic indication (hypertension or cardiac)	1.04 [0.15;7.42] ^C	1/974 164/165,775	165	974		ref
S13539 R54083	Bateman_Nordic - Beta-blockers, 2018	Cleft lip or palate	1st trimester	population based cohort retrospective	unexposed, sick	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	2.26 [0.47;10.80]	3/682 4/2,895	7	682		ref
S13791 R54090	Bateman_USMAX - Beta-blockers, 2018	Cleft lip or palate	1st trimester	retrospective cohort (claims database)	unexposed, sick	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	1.81 [0.52;6.33]	-/1,668 13/13,232	-	1,668		ref
					Total	3 studies	1.74 [0.72;4.17]		172	3,324
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Umbrella review (other published meta-analyses)