Beta-blockers (All routes except ocular) (versus unexposed) - Medication and Pregnancy KB

Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Genital anomalies

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17127 R71757	Delteil - Beta-blockers, 2024	Genital system malformations	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No Indications Antihypertensive: Only chronic indication (hypertension or cardiac)	1.28 [0.41;3.98] ^C	3/974 400/165,775	403	974		ref
S13935 R54559	Vasilakis-Scaramozza - Beta-blockers, 2013	Genital anomalies	1st trimester	retrospective cohort	unexposed (general population or NOS)	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	2.80 [0.70;11.90]	3/215 4/682	7	215		ref
					Total	2 studies	1.74 [0.72;4.22]		410	1,189
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded