Beta-blockers (All routes except ocular) (versus unexposed) - Medication and Pregnancy KB

Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Limb defects

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17127 R71756	Delteil - Beta-blockers, 2024	Musculoskeletal malformations	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No Indications Antihypertensive: Only chronic indication (hypertension or cardiac)	1.80 [0.74;4.34] ^C	5/974 475/165,775	480	974		ref
S13935 R54560	Vasilakis-Scaramozza - Beta-blockers, 2013	Limb anomalies, excluding clubfoot.	1st trimester	retrospective cohort	unexposed (general population or NOS)	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	6.40 [0.60;74.20]	2/215 1/682	3	215		ref
S13584 R52673	Queisser-Luft - Beta-blockers, 1996	Musculoskeletal system malformations	throughout pregnancy	nested case control	unexposed (general population or NOS)	Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified	1.50 [0.20;11.00]	-/- 0/-	-	-		ref
					Total	3 studies	1.99 [0.92;4.28]		483	1,189
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded