Beta-blockers (All routes except ocular) (versus unexposed) updated on 12-17-2024

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13809
R54307		 Hoeltzenbein c - Bisoprolol, 2018 Elective termination of pregnancies (ETOPs) at least 1st trimester prospective cohort unexposed, disease free Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 0.80 [0.40;1.60] 14/339   33/678 47 339
ref
Total 1 studies 0.80 [0.40;1.60] 47 339
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hoeltzenbein c - Bisoprolol, 2018Hoeltzenbein c - Bisoprolol, 2018 0.80[0.40; 1.60]473390%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.80[0.40; 1.60]47339 -NAHoeltzenbein c - Bisoprolol, 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.80[0.40; 1.60]47339 -NAHoeltzenbein c - Bisoprolol, 2018 1 Tags Adjustment   - Yes  - Yes 0.80[0.40; 1.60]47339 -NAHoeltzenbein c - Bisoprolol, 2018 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 0.80[0.40; 1.60]47339 -NAHoeltzenbein c - Bisoprolol, 2018 1 All studiesAll studies 0.80[0.40; 1.60]47339 -NAHoeltzenbein c - Bisoprolol, 2018 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.80[0.40; 1.60]47339 -NAHoeltzenbein c - Bisoprolol, 2018 10.510.01.0